Activation and migration of CD8 T cells in the intestinal mucosa
- Author(s)
- Kim, SK; Reed, DS; Heath, WR; Carbone, F; Lefrancois, L;
- Details
- Publication Year 1997-11-01,Volume 159,Issue #9,Page 4295-4306
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The activation of CD8 T cells was studied using transgenic mice expressing an MHC class I-restricted OVA-specific TCR (OT-I), Immunization of OT-l mice resulted in activation of lymph node T cells and up-regulation of expression of B220, CD11a, and CD44 and caused a preferential loss of mucosal-type T cells from the periphery, Immunization induced dramatic changes in intestinal lymphocytes, including the appearance of a CD11a high population that resembled peripheral T cells and induced a primary cytolytic response, Activation of adoptively transferred OT-l cells induced migration of CD8 T cells into the lamina propria and intraepithelial lymphocyte compartments, The results suggest that Ag presentation in the intestinal epithelium occurs, and that CD8 cells activated in the periphery can readily enter the mucosa during an ongoing immune response.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- INTRAEPITHELIAL LYMPHOCYTES; IN-VIVO; MONOCLONAL-ANTIBODIES; EPITHELIAL-CELLS; GAMMA-DELTA; TOLERANCE INDUCTION; RECEPTOR-ALPHA/BETA; CYTOLYTIC ACTIVITY; ALPHA-4 INTEGRINS; DENDRITIC CELLS
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- Refer to copyright notice on published article.
Creation Date: 1997-11-01 12:00:00