Pathogenesis of malaria
- Author(s)
- Clark, IA; Schofield, L;
- Details
- Publication Year 2000-10,Volume 16,Issue #10,Page 451-454
- Journal Title
- PARASITOLOGY TODAY
- Publication Type
- Journal Article
- Abstract
- As the mortality rate of 20-30% for severe falciparum malaria under even the best clinical conditions testifies, access to anti-malarial drugs is not sufficient to prevent an appreciable mortality from this disease. Understanding the cause of death at a cellular level is essential if additional rational treatments are to be developed. Here, Ian Clark and Louis Schofield discuss recent work presented at the Molecular Approaches to Malaria conference, Lorne, Australia, 2-5 February 2000, that updates the cytokine-based concept of malarial disease.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- PLASMODIUM-FALCIPARUM MALARIA; TUMOR NECROSIS FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; CHRONIC SALICYLATE INTOXICATION; VASCULAR ENDOTHELIAL-CELLS; HUMAN CEREBRAL MALARIA; PROTEIN-KINASE-C; NITRIC-OXIDE; GLYCOSYLPHOSPHATIDYLINOSITOL TOXIN; SIGNAL-TRANSDUCTION
- Publisher's Version
- https://doi.org/10.1016/S0169-4758(00)01757-9
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-10-01 12:00:00