Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: Modulation of interferon-regulated gene expression by Rel/nuclear factor kappa B
- Author(s)
- Grumont, RJ; Gerondakis, S;
- Details
- Publication Year 2000-04-17,Volume 191,Issue #8,Page 1281-1291
- Journal Title
- JOURNAL OF EXPERIMENTAL MEDICINE
- Publication Type
- Journal Article
- Abstract
- In lymphocytes, the Rel transcription factor is essential in establishing a pattern of gene expression that promotes cell proliferation, survival, and differentiation. Here we show that mitogen-induced expression of interferon (IFN) regulatory factor 4 (IRF-4), a lymphoid-specific member of the IFN family of transcription factors, is Rel dependent. Consistent with IRF-4 functioning as a repressor of IFN-induced gene expression, the absence of IRF-4 expression in c-rel(-/-) B cells coincided with a greater sensitivity of these cells to the antiproliferative activity of IFNs. In turn, enforced expression of an IRF-4 transgene restored IFN modulated c-rel(-/-) B cell proliferation to that of wild-type cells. This cross-regulation between two different signaling pathways represents a novel mechanism that Rel/nuclear factor kappa B can repress the transcription of IFN-regulated genes in a cell type-specific manner.
- Publisher
- ROCKEFELLER UNIV PRESS
- Keywords
- T-CELL LEUKEMIA; TRANSCRIPTION FACTORS; FACTOR FAMILY; NUCLEOTIDE-SEQUENCE; EXHIBIT DEFECTS; SYNTHETASE CDNA; NUCLEAR FACTOR; P65 SUBUNIT; DNA; ACTIVATION
- Publisher's Version
- https://doi.org/10.1084/jem.191.8.1281
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-04-17 12:00:00