Safety and immunogenicity of a three-component blood-stage malaria vaccine in adults living in an endemic area of Papua New Guinea
Details
Publication Year 2000-05-22, Volume 18, Issue #23, Page 2504-2511
Journal Title
VACCINE
Publication Type
Journal Article
Abstract
A Phase I safety and immunogenicity study with a three-component blood-stage malaria vaccine was conducted in adult male subjects living in an endemic area of Papua New Guinea. The preparations were recombinant proteins which corresponded to parts of the two merozoite surface proteins of Plasmodium falciparum (MSP1 and 2), and of the ring-infected erythrocyte surface antigen (RESA). The three proteins were emulsified with the adjuvant Montanide ISA720. Ten subjects were injected twice (four weeks apart) with the vaccine formulation and two with the adjuvant alone. Mild pain at the site of injection was reported by about half of the subjects but no systemic reaction related to the formulation occurred. There was a sharp rise in geometric mean stimulation index after the second dose compared to baseline for MSPI and RESA, while the rise was small for MSP2. Geometric mean antibody titres increased for MSP1 during the study, whereas they hardly changed for MSP2 and RESA. The vaccine formulation was safe when used in an already immune population. The vaccine induced good cellular responses, especially for MSP1 and RESA. Boosting of humoral responses was weak, probably because of high baseline antibody levels. (C) 2000 Elsevier Science Ltd. All rights reserved.
Publisher
ELSEVIER SCI LTD
Keywords
MEROZOITE SURFACE ANTIGEN-2; EAST SEPIK PROVINCE; HUMORAL RESPONSE; CLINICAL MALARIA; GAMBIAN INFANTS; PILOT SAFETY; WOSERA AREA; SPF66; CHILDREN; EPIDEMIOLOGY
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Creation Date: 2000-05-22 12:00:00
Last Modified: 0001-01-01 12:00:00
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