Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis
- Stanley, EG; Biben, C; Allison, J; Hartley, L; Wicks, IP; Campbell, IK; McKinley, M; Barnett, L; Koentgen, F; Robb, L; Harvey, RP;
Publication Year 2000-04, Volume 26, Issue #4, Page 259-264
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- Journal Article
- The mouse Cer1 (mCer1, Cer-I Cerr1) gene encodes one member of a family of cytokines structurally and functionally related to the Xenopus head-inducing factor, Cerberus (xCer). We generated a mouse line in which the Cer1 gene was inactivated by replacing the first coding exon with a lacZ reporter gene. Mice homozygous for this allele (Cer1(lacZ)) showed no apparent perturbation of embryogenesis or later development. However, the lacZ reporter revealed a number of hitherto uncharacterised sites of Cer1 expression in late fetal and adult tissues. Preliminary analysis suggests that Cer1 is not essential for their morphogenesis, differentiation, or homeostasis. genesis 26:259-264, 2000. (C) 2000 Wiley-Liss, Inc.
- ANTERIOR PRIMITIVE ENDODERM; CERBERUS-RELATED GENE; HEAD INDUCTION; SECRETED PROTEINS; BMP; XENOPUS; FAMILY; MORPHOGENESIS; GASTRULATION; ASYMMETRY
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Creation Date: 2000-04-01 12:00:00Last Modified: 0001-01-01 12:00:00