Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis
- Author(s)
- Stanley, EG; Biben, C; Allison, J; Hartley, L; Wicks, IP; Campbell, IK; McKinley, M; Barnett, L; Koentgen, F; Robb, L; Harvey, RP;
- Details
- Publication Year 2000-04,Volume 26,Issue #4,Page 259-264
- Journal Title
- GENESIS
- Publication Type
- Journal Article
- Abstract
- The mouse Cer1 (mCer1, Cer-I Cerr1) gene encodes one member of a family of cytokines structurally and functionally related to the Xenopus head-inducing factor, Cerberus (xCer). We generated a mouse line in which the Cer1 gene was inactivated by replacing the first coding exon with a lacZ reporter gene. Mice homozygous for this allele (Cer1(lacZ)) showed no apparent perturbation of embryogenesis or later development. However, the lacZ reporter revealed a number of hitherto uncharacterised sites of Cer1 expression in late fetal and adult tissues. Preliminary analysis suggests that Cer1 is not essential for their morphogenesis, differentiation, or homeostasis. genesis 26:259-264, 2000. (C) 2000 Wiley-Liss, Inc.
- Publisher
- WILEY-LISS
- Keywords
- ANTERIOR PRIMITIVE ENDODERM; CERBERUS-RELATED GENE; HEAD INDUCTION; SECRETED PROTEINS; BMP; XENOPUS; FAMILY; MORPHOGENESIS; GASTRULATION; ASYMMETRY
- Publisher's Version
- https://doi.org/10.1002/(SICI)1526-968X(200004)26:4<259::AID-GENE70>3.0.CO;2-V
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-04-01 12:00:00