Toxic shock syndrome associated with newly diagnosed type I diabetes
- Author(s)
- Couper, JJ; Kallincos, N; Pollard, A; Honeyman, M; Prager, P; Harrison, LC; Rischmueller, M;
- Details
- Publication Year 2000-06,Volume 36,Issue #3,Page 279-282
- Journal Title
- JOURNAL OF PAEDIATRICS AND CHILD HEALTH
- Publication Type
- Journal Article
- Abstract
- Studies of two post-mortem pancreata of children at the onset of type I diabetes have suggested activation and expansion of islet infiltrating T cells by a superantigen. We present the first reported case of a superantigen mediated disease, toxic shock syndrome (TSS), occurring at the diagnosis of type I diabetes. A 12-year-old girl presented with TSS and newly diagnosed diabetes with ketoacidosis. At presentation she was unconscious, febrile and hypotensive, with a desquamating erythematous rash and Kussmaul breathing. During resuscitation, her renal impairment, diarrhoea, thrombocytopaenia and ketoacidosis resolved. Vaginal discharge and blood cultures grew Staphylococcus aureus. T cell studies at 2 weeks after diagnosis detected a high level of spontaneous and islet antigen-specific proliferation with associated interleukin-10 production compared to human leucocyte antigen DR matched controls.
- Publisher
- BLACKWELL SCIENCE ASIA
- Keywords
- AUTOIMMUNE-DISEASES; SUPERANTIGENS
- Publisher's Version
- https://doi.org/10.1046/j.1440-1754.2000.00475.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-06-01 12:00:00