REGULATION OF NEURAL PRECURSOR DIFFERENTIATION IN THE EMBRYONIC AND ADULT FOREBRAIN
- Author(s)
- Bartlett, PF; RICHARDS, LR; Kilpatrick, TJ; TALMAN, PS; BAILEY, KA; Brooker, GJF; Dutton, R; Koblar, S; Nurcombe, V; FORD, M; Cheema, SS; LIKIARDOPOULOS, V; Murphy, M;
- Details
- Publication Year 1995-08,Volume 22,Issue #8,Page 559-562
- Journal Title
- CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Publication Type
- Journal Article
- Abstract
- 1. Precursors form the neuroepithelium of the developing cortex and also from the adult sub-ventricular zone, can be cloned in vitro after stimulation with fibroblast growth factor (FGF)-2 and have the potential to give rise to both neurons and glia. The generation of neurons from these clones can be stimulated by either a factor derived from an astrocyte-precursor line, Ast-1, or FGF-1. 2. Neuronal differentiation stimulated by FGF-1 can be inhibited by diacylglycerol-lipase inhibitor and mimicked by arachidonic acid, suggesting that the neuronal differentiation is signalled through the PCL gamma pathway. 3. The sequential expression of FGF-2 and FGF-1 within the developing forebrain neuroepithelium fits with the different functions the two FGF play in precursor regulation. 4. We have shown that the precursor response to FGF-1 is regulated by a heparan sulphate proteoglycan (HSPG) expressed within the developing neuroepithelium. Precursors restricted to the astrocyte cell lineage can be stimulated by epidermal growth factor or FGF-2; however, the differentiation into GFAP positive astrocytes appears to require a cytokine acting through the leukaemia inhibitory factor beta receptor.
- Publisher
- BLACKWELL SCIENCE PUBL AUSTR
- Keywords
- CENTRAL-NERVOUS-SYSTEM; CELLS; NEURONS; GROWTH; PROLIFERATION; ASTROCYTES; GENERATION; INVITRO; BRAIN
- Publisher's Version
- https://doi.org/10.1111/j.1440-1681.1995.tb02066.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1995-08-01 12:00:00