Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury
- Author(s)
- Coulson, EJ; Reid, K; Murray, SS; Cheema, SS; Bartlett, PF;
- Details
- Publication Year 2000-07,Volume 27,Issue #7,Page 537-541
- Journal Title
- CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Publication Type
- Journal Article
- Abstract
- 1. The neurotrophin receptor p75NTR has been shown to mediate neuronal cell death after nerve injury. 2. Down-regulation of p75NTR by antisense oligonucleotides is able to inhibit both sensory and motor neuron death and this treatment is more effective than treatment with growth factors. 3. p75NTR induces cell death by a unique death signalling pathway involving transcription factors (nuclear factor kappa B and c-jun), Bcl-2 family members and caspases.
- Publisher
- BLACKWELL SCIENCE ASIA
- Keywords
- NERVE GROWTH-FACTOR; NF-KAPPA-B; AFFINITY NGF RECEPTOR; DORSAL-ROOT GANGLIA; CHOLINE-ACETYLTRANSFERASE; PC12 CELLS; APOPTOSIS; BCL-2; ACTIVATION; EXPRESSION
- Publisher's Version
- https://doi.org/10.1046/j.1440-1681.2000.03295.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-07-01 12:00:00