Gigantism in mice lacking suppressor of cytokine signalling-2
Details
Publication Year 2000-06-29, Volume 405, Issue #6790, Page 1069-1073
Journal Title
NATURE
Publication Type
Journal Article
Abstract
Suppressor of cytokine signalling-2 (SOCS-2) is a member of the suppressor of cytokine signalling family, a group of related proteins implicated in the negative regulation of cytokine action through inhibition of the Janus kinase (JAK) signal transducers and activators of transcription (STAT) signal-transduction pathway(1). Here we use mice unable to express SOCS-2 to examine its function in vivo. SOCS-2(-/-) mice grew significantly larger than their wild-type littermates. Increased body weight became evident after weaning and was associated with significantly increased long bone lengths and the proportionate enlargement of most organs. Characteristics of deregulated growth hormone and insulin-like growth factor-I (IGF-I) signalling, including decreased production of major urinary protein, increased local IGF-I production, and collagen accumulation in the dermis, were observed in SOCS-2-deficient mice, indicating that SOCS-2 may have an essential negative regulatory role in the growth hormone/IGF-I pathway.
Publisher
MACMILLAN PUBLISHERS LTD
Keywords
GROWTH-FACTOR-I; RECEPTOR GENE-EXPRESSION; TRANSGENIC MICE; C-MPL; HORMONE; INSULIN; LIVER; SOCS-3; DEFICIENCIES; TRANSDUCTION
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2000-06-29 12:00:00
Last Modified: 0001-01-01 12:00:00
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