The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF
- Author(s)
- Campbell, IK; Rich, MJ; Bischof, RJ; Hamilton, JA;
- Details
- Publication Year 2000-07,Volume 68,Issue #1,Page 144-150
- Journal Title
- JOURNAL OF LEUKOCYTE BIOLOGY
- Publication Type
- Journal Article
- Abstract
- There is increasing evidence that the colony-stimulating factors (CSFs) may play a part in chronic inflammatory autoimmune diseases, such as rheumatoid arthritis (RA). We examined the involvement of macrophage CSF (M-CSF or CSF-1) and granulocyte CSF (G-CSF) in collagen-induced arthritis (CIA), a murine model of EW, Daily injections of M-CSF or G-CSF, 20-24 days postprimary immunization with type II collagen, exacerbated disease symptoms in suboptimally immunized DBA/1 mice. Support for the involvement of endogenous M-CSF in CIA was obtained by studies in which neutralizing monoclonal antibody reduced the severity of established CIA and also by studies showing the resistance of M-CSF-deficient op/op mice to CIA induction, These studies show that M-CSF and G-CSF can be proinflammatory in CIA and provide evidence that macroghage- and granulocyte-lineage tells can exacerbate CIA. Our results also show that M-CSF-dependent cells are essential for CIA development, suggesting M-CSF may be a suitable target for therapeutic intervention in RA.
- Publisher
- FEDERATION AMER SOC EXP BIOL
- Keywords
- CHRONIC INFLAMMATORY ARTHRITIS; TUMOR-NECROSIS-FACTOR; ACTIVE RHEUMATOID-ARTHRITIS; HUMAN ARTICULAR-CARTILAGE; FELTYS-SYNDROME; GENE-EXPRESSION; DENDRITIC CELLS; SYNOVIAL FIBROBLASTS; PROGENITOR CELLS; FACTOR-ALPHA
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Creation Date: 2000-07-01 12:00:00