CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types
- Author(s)
- O'Connor, L; Harris, AW; Strasser, A;
- Details
- Publication Year 2000-03-01,Volume 60,Issue #5,Page 1217-1220
- Journal Title
- CANCER RESEARCH
- Publication Type
- Journal Article
- Abstract
- The tumor suppressor p53 exerts its antioncogenic effects in cells chiefly by regulating their progression through the cell cycle and by inducing cell death. It has been claimed that p53-transduced apoptosis involves the death receptor CD95 (Fas/APO-1). We report that thymocytes from mice Lacking functional Fas ligand (gld) show normal sensitivity to apoptosis transduced by p53, and that hepatocytes from p53(-/-) mice have normal sensitivity to apoptosis triggered through ligation of CD95, p53 and CD95, therefore, function in independent pathways to cell death in these diverse fell types.
- Publisher
- AMER ASSOC CANCER RESEARCH
- Keywords
- TUMOR-SUPPRESSOR PROTEIN; DNA-DAMAGE; PATHWAYS; DEATH; MICE; ACTIVATION; GENE; IRRADIATION; THYMOCYTES; INDUCTION
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- Refer to copyright notice on published article.
Creation Date: 2000-03-01 12:00:00