Pancreatic islet xenotransplantation: the potential for tolerance induction
Author(s)
Smith, RM; Mandel, TE;
Details
Publication Year 2000-01, Volume 21, Issue #1, Page 42-48
Journal Title
IMMUNOLOGY TODAY
Publication Type
Journal Article
Abstract
Pancreatic islet transplantation can correct the disordered glucose metabolism of IDDM, but its widespread application will probably need non-human source of islets. Immunosuppression presently available to control rejection of xenografts is unsustainable clinically. However, experiments in rodents suggest that xenogeneic islets can survive without continuing immunosuppression and experiments in large outbred species suggest that clinically applicable protocols are possible.
Publisher
ELSEVIER SCI LTD
Keywords
CELL-DEPLETED MICE; FETAL PANCREAS; XENOGRAFT REJECTION; TRANSPLANTATION TOLERANCE; ENDOGENOUS RETROVIRUS; IMMUNODEFICIENT MOUSE; ALLOGRAFT-REJECTION; CYNOMOLGUS MONKEYS; DIABETIC-PATIENTS; IMMUNE-RESPONSE
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2000-01-01 12:00:00
Last Modified: 0001-01-01 12:00:00
An error has occurred. This application may no longer respond until reloaded. Reload 🗙