Pancreatic islet xenotransplantation: the potential for tolerance induction
Publication Year 2000-01, Volume 21, Issue #1, Page 42-48
- Journal Title
- IMMUNOLOGY TODAY
- Publication Type
- Journal Article
- Pancreatic islet transplantation can correct the disordered glucose metabolism of IDDM, but its widespread application will probably need non-human source of islets. Immunosuppression presently available to control rejection of xenografts is unsustainable clinically. However, experiments in rodents suggest that xenogeneic islets can survive without continuing immunosuppression and experiments in large outbred species suggest that clinically applicable protocols are possible.
- ELSEVIER SCI LTD
- CELL-DEPLETED MICE; FETAL PANCREAS; XENOGRAFT REJECTION; TRANSPLANTATION TOLERANCE; ENDOGENOUS RETROVIRUS; IMMUNODEFICIENT MOUSE; ALLOGRAFT-REJECTION; CYNOMOLGUS MONKEYS; DIABETIC-PATIENTS; IMMUNE-RESPONSE
- Publisher's Version
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-01-01 12:00:00Last Modified: 0001-01-01 12:00:00