Manipulation of mucosa-mediated immunoregulation
- Author(s)
- Harrison, LC; Martinez, NR; Solly, NR; Hanninen, A;
- Details
- Publication Year 2000-01,Volume 8,Issue #1-2,Page 28-30
- Journal Title
- IMMUNOLOGIST
- Publication Type
- Journal Article
- Abstract
- Mucosal administration of antigen is known to have tolerogenic potential; however, it may also prime systemic cytotoxic T lymphocytes (CTL) and even exacerbate autoimmune disease. Here, Leonard C. Harrison and colleagues use the nonobese diabetic (NOD) mouse model of diabetes to develop strategies to minimize immunity and maximize tolerance, that have broad implications for other diseases.
- Publisher
- HOGREFE & HUBER PUBLISHERS
- Keywords
- MYELIN BASIC-PROTEIN; CD4(+) T-CELLS; NOD MICE; RESPONSES; INSULIN; SUPPRESSION; INDUCTION
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-01-01 12:00:00