Cytotoxic T lymphocytes and cross-priming
- Author(s)
- Heath, WR; Clarke, SMR; Davey, GM; Kurts, C; Lew, AM; Li, M; Mintern, J; Sutherland, RM; Carbone, FR; Miller, JFAP;
- Details
- Publication Year 2000-01,Volume 8,Issue #1-2,Page 16-17
- Journal Title
- IMMUNOLOGIST
- Publication Type
- Journal Article
- Abstract
- Professional antigen-presenting cells (APCs) can capture and present exogenous antigen on major histocompatibility class (MHC) I molecules to cytotoxic T cells (CTLs), by the poorly understood process of cross-presentation. Here,William R. Heath and colleagues show that APCs scan the periphery and present class I-restricted tissue derived antigens to naive CTLs in the lymph nodes. They outline a working model of the process and outline outstanding questions.
- Publisher
- HOGREFE & HUBER PUBLISHERS
- Keywords
- CELL HELP; ANTIGENS; TOLERANCE; IMMUNITY
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-01-01 12:00:00