The neurotrophins act synergistically with LIF and members of the TGF-beta superfamily to promote the survival of spiral ganglia neurons in vitro
- Author(s)
- Marzella, PL; Gillespie, LN; Clark, GM; Bartlett, PF; Kilpatrick, TJ;
- Details
- Publication Year 1999-12,Volume 138,Issue #1-2,Page 73-80
- Journal Title
- HEARING RESEARCH
- Publication Type
- Journal Article
- Abstract
- A number of growth factor families have been implicated in normal inner ear development, auditory neuron survival and protection. Several growth factors, including transforming growth factor-beta 5 (TGF-beta 5) and TGF-beta 3, neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) were tested for their ability, individually or in combination, to promote auditory neuron survival in dissociated cell cultures of early rat post-natal spiral ganglion cells (SGCs). The results indicate that at discrete concentrations all growth factors act in an additive fashion and some in synergy when promoting neuronal survival. These findings support the hypothesis that growth factors from different families may be interdependent when sustaining neuronal integrity. (C) 1999 Elsevier Science B.V. All rights reserved.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- LEUKEMIA INHIBITORY FACTOR; ADULT AUDITORY NEURONS; NERVE GROWTH-FACTOR; SENSORY NEURONS; MESSENGER-RNA; IN-VITRO; HAIR-CELLS; INNER-EAR; NT-3; BDNF
- Publisher's Version
- https://doi.org/10.1016/S0378-5955(99)00152-5
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-12-01 12:00:00