The beta cell in autoimmune diabetes: Many mechanisms and pathways of loss
Details
Publication Year 2000-01,Volume 11,Issue #1,Page 11-15
Journal Title
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Publication Type
Journal Article
Abstract
Death of pancreatic beta cells is the final step in the pathogenesis of type I diabetes before it becomes clinically apparent. Applying recent basic research about how cells die to rite clinical problem of diabetes is a current opportunity and challenge. To date, perforin is the only factor definitely implicated in beta-cell killing in the non-obese diabetic (NOD) mouse model, although some perforin-deficient NOD mice develop diabetes. Our results suggest that other factors that cause beta-cell death remain to be identified.
Publisher
ELSEVIER SCIENCE LONDON
Keywords
NITRIC-OXIDE SYNTHASE; NOD MICE; INTERFERON-GAMMA; TNF-ALPHA; PANCREATIC-ISLETS; LOCAL EXPRESSION; MOUSE; APOPTOSIS; FAS; DESTRUCTION
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2000-01-01 12:00:00
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