The beta cell in autoimmune diabetes: Many mechanisms and pathways of loss
- Author(s)
- Kay, TWH; Thomas, HE; Harrison, LC; Allison, J;
- Details
- Publication Year 2000-01,Volume 11,Issue #1,Page 11-15
- Journal Title
- TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Publication Type
- Journal Article
- Abstract
- Death of pancreatic beta cells is the final step in the pathogenesis of type I diabetes before it becomes clinically apparent. Applying recent basic research about how cells die to rite clinical problem of diabetes is a current opportunity and challenge. To date, perforin is the only factor definitely implicated in beta-cell killing in the non-obese diabetic (NOD) mouse model, although some perforin-deficient NOD mice develop diabetes. Our results suggest that other factors that cause beta-cell death remain to be identified.
- Publisher
- ELSEVIER SCIENCE LONDON
- Keywords
- NITRIC-OXIDE SYNTHASE; NOD MICE; INTERFERON-GAMMA; TNF-ALPHA; PANCREATIC-ISLETS; LOCAL EXPRESSION; MOUSE; APOPTOSIS; FAS; DESTRUCTION
- Publisher's Version
- https://doi.org/10.1016/S1043-2760(99)00210-6
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-01-01 12:00:00