Effect of pre-existing cytotoxic T lymphocytes on therapeutic vaccines
- Author(s)
- Sherritt, MA; Gardner, J; Elliott, SL; Schmidt, C; Purdie, D; Deliyannis, G; Heath, WR; Suhrbier, A;
- Details
- Publication Year 2000-02,Volume 30,Issue #2,Page 671-677
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Therapeutic vaccines which aim to induce CD8(+) cytotoxic T lymphocyte (CTL) responses will often be required to perform in the presence of pre-existing CTL which recognize epitopes within the vaccine. Here we explore the ability of a viral vaccine vector presenting several co-dominant CTL epitopes to prime CTL responses in animals that have a pre-existing CTL response to one of the epitopes in the vaccine. The vaccine was usually capable of inducing multiple new responses, suggesting that immunodomination effects of pre-existing CTL may generally be minimal following vaccination. However, when large numbers of pre-existing CTL were present, a novel type of immune modulation was observed whereby (1) the vaccine failed to prime efficiently new CTL responses that were restricted by the same MHC gene as the pre-existing responses, and (2) vaccine-induced CTL responses restricted by other MHC genes were enhanced. These results may have implications for therapeutic multi-epitope vaccines for diseases like HIV and melanoma, which aim to broaden CTL responses.
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- CLASS-I GENES; DIFFERENTIAL REGULATION; POSITIVE SELECTION; DENDRITIC CELLS; EPITOPES; ANTIGEN; IMMUNODOMINANCE; INTERFERON; INFECTION; VACCINATION
- Publisher's Version
- https://doi.org/10.1002/1521-4141(200002)30:2<671::AID-IMMU671>3.0.CO;2-H
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-02-01 12:00:00