Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene
- Author(s)
- Brodnicki, TC; McClive, P; Couper, S; Morahan, G;
- Details
- Publication Year 2000-01,Volume 51,Issue #1,Page 37-41
- Journal Title
- IMMUNOGENETICS
- Publication Type
- Journal Article
- Abstract
- Type 1 diabetes is a multigenic autoimmune disease, the genetic basis for which is perhaps best characterized in the nonobese diabetic (NOD) mouse model. We previously located a NOD diabetes susceptibility locus, designated Idd11, on mouse Chromosome (Chr) 4 by analyzing diabetic backcross mice produced after crossing NOD/Lt with the nondiabetic resistant strain C57BL/6 (B6) strain. In order to confirm Idd11 and further refine its location, three NOD congenic mouse strains with different B6 derived intervals within Chr 4 were generated. Two of the congenic strains had a significant decrease in the cumulative incidence of diabetes compared with NOD/Lt control mice. The third NOD congenic strain, containing a B6 interval surrounding the Slc9a1 locus, was not protected against diabetes. These results define a new distal boundary for Idd11 and eliminate the Slc9a1 gene as a candidate. The Idd11 locus has now been definitively mapped to a 13cM interval on mouse Chr 4.
- Publisher
- SPRINGER VERLAG
- Keywords
- DEPENDENT DIABETES-MELLITUS; SUSCEPTIBILITY GENES; MICE; RESISTANCE; LOCUS; IDENTIFICATION; CHROMOSOME-3; CROSSES; ALLELES; GENOME
- Publisher's Version
- https://doi.org/10.1007/s002510050006
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-01-01 12:00:00