Rat oligodendroglia express c-met and focal adhesion kinase, protein tyrosine kinases implicated in regulating epithelial cell motility
- Author(s)
- Kilpatrick, TJ; Ortuno, D; Bucci, T; Lai, C; Lemke, G;
- Details
- Publication Year 2000-01-21,Volume 279,Issue #1,Page 5-8
- Journal Title
- NEUROSCIENCE LETTERS
- Publication Type
- Journal Article
- Abstract
- Oligodendrocytes, the myelinating cells of the central nervous system, arise from a profilerating pool of motile progenitor cells. The proliferation and survival of these cells is dependent on signal transduction via several protein tyrosine kinases (PTKs) including receptors for fibroblast growth factor -2, the platelet-derived growth factor receptors and the neurotrophin receptor, trkC. We hypothesized that additional PTKs could also influence oligodendroglial development. Utilizing RTPCR, we amplified from post-natal day 6 rat oligodendroglia 17 distinct kinase domain sequences, 14 of which were not previously known to be expressed by oligodendroglia. Amongst the sequences identified were the c-met and Fak genes, whose protein products regulate the motility of other epithelial cell types. Utilizing immunohistochemistry, we confirmed that both c-met and Fak are expressed by cultured oligodendroglia, suggesting that these proteins could also be implicated in regulating the motility of these cells. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.
- Publisher
- ELSEVIER SCI IRELAND LTD
- Keywords
- HEPATOCYTE GROWTH-FACTOR; MONOCLONAL-ANTIBODIES; PROGENITOR CELLS; NERVOUS-SYSTEM; FAMILY; DIFFERENTIATION; SURVIVAL; RECEPTOR; NEUROTROPHIN-3; ASTROCYTES
- Publisher's Version
- https://doi.org/10.1016/S0304-3940(99)00928-3
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-01-21 12:00:00