MICE LACKING THE C-REL PROTOONCOGENE EXHIBIT DEFECTS IN LYMPHOCYTE-PROLIFERATION, HUMORAL IMMUNITY, AND INTERLEUKIN-2 EXPRESSION
- Author(s)
- Kontgen, F; Grumont, RJ; Strasser, A; Metcalf, D; Li, RL; Tarlinton, D; Gerondakis, S;
- Details
- Publication Year 1995-08-15,Volume 9,Issue #16,Page 1965-1977
- Journal Title
- GENES & DEVELOPMENT
- Publication Type
- Journal Article
- Abstract
- The c-rel proto-oncogene, which is expressed predominantly in hemopoietic cells encodes a subunit of the NF-kappa B-like family of transcription factors. In mice with an inactivated c-rel gene, whereas development of cells from all hemopoietic lineages appeared normal, humoral immunity was impaired and mature B and T cells were found to be unresponsive to most mitogenic stimuli. Phorbol ester and calcium ionophore costimulation, in contrast to certain membrane receptor-mediated signals, overcame the T cell-proliferative defect, demonstrating that T cell proliferation occurs by Rel-dependent and -independent mechanisms. The ability of exogenous interleukin-2 to restore T cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function.
- Publisher
- COLD SPRING HARBOR LAB PRESS
- Keywords
- NF-KAPPA-B; DNA-BINDING SUBUNIT; T-CELLS; DEPENDENT ACTIVATION; GENE; TRANSCRIPTION; PROTEINS; PROMOTER; INHIBITOR; DORSAL
- Publisher's Version
- https://doi.org/10.1101/gad.9.16.1965
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1995-08-15 12:00:00