The helix-loop-helix gene SCL: Implicated in T-cell acute lymphoblastic leukaemia and in normal haematopoietic development
- Author(s)
- Robb, L; Begley, CG;
- Details
- Publication Year 1996-06,Volume 28,Issue #6,Page 609-618
- Journal Title
- INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- The SCL gene encodes a member of the helix-loop-helix family of transcription factors and was first identified through its involvement in a chromosomal translocation in a human leukaemic cell line. SCL is now recognized to be aberrantly expressed in most human T-cell leukaemias. In around 25% of cases SCL overexpression is associated with identifiable chromosomal abnormalities but in other cases the mechanism of ectopic expression has not yet been identified. SCL is normally expressed in haematopoietic progenitor cells, erythroid cells, mast cells and megakaryocytes. Gene delivery experiments using haematopoietic cell lines and the recent creation of mice with a null mutation of the SCL gene have demonstrated that SCL plays a crucial role in haematopoietic commitment and differentiation. (C) 1996 Elsevier Science Ltd
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- SITE-SPECIFIC DELETIONS; DNA-BINDING MOTIF; ERYTHROID-DIFFERENTIATION; CHROMOSOMAL TRANSLOCATION; TAL-1 GENE; MOLECULAR-CLONING; ACUTE-LEUKEMIA; PROTEINS; LOCUS; DISRUPTION
- Publisher's Version
- https://doi.org/10.1016/1357-2725(96)00006-4
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1996-06-01 12:00:00