Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus
- Author(s)
- Morahan, G; Huang, DX; Tait, BD; Colman, PG; Harrison, LC;
- Details
- Publication Year 1996-06-21,Volume 272,Issue #5269,Page 1811-1813
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- Insulin-dependent diabetes mellitus (IDDM) is a multigenic autoimmune disease. An IDDM susceptibility gene was mapped to chromosome 2q34. This gene may act early in diabetogenesis, because ''preclinical'' individuals also showed linkage, Human leukocyte antigen (HLA)-disparate, but not HLA-identical, sibs showed linkage, which was even stronger in families with affected females. The genes encoding insulin-like growth factor-binding proteins 2 and 5 were mapped to a 4-megabase pair interval near this locus, These results indicate the existence of a gene that acts at an early stage in IDDM development, screening for which may identify a specific subset of at-risk individuals.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- GENETIC-ANALYSIS; LOCALIZATION; MICE; IDENTIFICATION; LINKAGE; RECEPTOR; PROTEIN; GENOME; LOCUS
- Publisher's Version
- https://doi.org/10.1126/science.272.5269.1811
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1996-06-21 12:00:00