Thymic dendritic cell precursors: Relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny

Author(s): Wu, L; Li, CL; Shortman, K;
Details: Publication Year 1996-09-01,Volume 184,Issue #3,Page 903-911
Journal Title: JOURNAL OF EXPERIMENTAL MEDICINE
Publication Type: Journal Article
Abstract: Successive T-precursors isolated from adult mouse thymus were examined for their developmental potential, by transfer to irradiated Ly 5-disparate recipients. The earliest, ''low CD4'' precursors formed T, B, and dendritic cells (DC), but not myeloid cells, in accordance with earlier studies. Surprisingly, the next downstream CD4(-)8(-)3(-)44(+)25(+) precursor population still formed DC as well as T cells although it no longer formed B or myeloid cells. Further downstream, the CD4(-)8(-)3(-)44(-)25(+) population formed only T cells. The thymic and splenic DC progeny of the early thymic precursors all expressed high levels of CD8 alpha, in contrast with normal splenic DC and the splenic DC progeny of bone marrow stem cells, which consisted of both CD8(-) and CD8(+) DC. A common precursor of T cells and of a subclass of DC is proposed, with CD8 alpha as a marker of the lymphoid-related DC lineage.
Publisher: ROCKEFELLER UNIV PRESS
Keywords: MOUSE THYMUS; RECEPTOR GENE; STEM-CELLS; EXPRESSION; COMMITMENT; THYMOCYTES; CD44; DIFFERENTIATION; POPULATION
Publisher's Version: https://doi.org/10.1084/jem.184.3.903
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1996-09-01 12:00:00