ASSESSMENT OF THE ROLE OF THE HUMORAL RESPONSE TO PLASMODIUM-FALCIPARUM MSP2 COMPARED TO RESA AND SPF66 IN PROTECTING PAPUA-NEW-GUINEAN CHILDREN FROM CLINICAL MALARIA
Details
Publication Year 1995-09, Volume 17, Issue #9, Page 493-501
Journal Title
PARASITE IMMUNOLOGY
Publication Type
Journal Article
Abstract
The prevalence and concentration of naturally acquired humoral response (IgG) to merozoite surface protein 2 (MSP2), RESA, SPf66 and crude schizont extract were measured in a population living in a malaria highly endemic area of Papua New Guinea. A prospective longitudinal study in 0.5-15 year old children was conducted for one year in order to examine the relationship between the humoral response to these antigens and subsequent susceptibility to clinical malaria using a series of clinical definitions. The prevalence and concentration of antibodies to all antigens increased with age. Such correlation with age was most marked for MSP2 recombinant proteins. When age and previous exposure were controlled for, only antibody levels to MSP2 recombinant proteins (3D7 and d3D7) and to RESA predicted a reduction in incidence rate of episodes of clinical malaria. Our results support the inclusion of the recombinant proteins of the 3D7 allelic family of merozoite surface antigen 2 and RESA into a subunit vaccine against malaria.
Publisher
BLACKWELL SCIENCE LTD
Keywords
ERYTHROCYTE SURFACE-ANTIGEN; ASEXUAL BLOOD STAGES; SYNTHETIC VACCINE; IMMUNE-RESPONSE; AOTUS MONKEYS; OWL MONKEYS; ANTIBODIES; PROTEIN; IMMUNIZATION; GP195
Rights Notice
Refer to copyright notice on published article.


Creation Date: 1995-09-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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