Molecular and clinical aspects of apoptosis

Author(s): Uren, AG; Vaux, DL;
Details: Publication Year 1996,Volume 72,Issue #1,Page 37-50
Journal Title: PHARMACOLOGY & THERAPEUTICS
Publication Type: Journal Article
Abstract: Unwanted cells are removed by physiological cell death processes that are highly throughout the animal kingdom. Physiological cell death plays an important role in development, tissue homeostasis and defence against viral infection and mutation. This review describes the molecular components that implement this process, the relevance of these to a variety of human diseases, and discusses the potential for novel therapies based on our understanding of them. Copyright (C) 1996 Elsevier Science Inc.
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Keywords: PROGRAMMED CELL-DEATH; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1-BETA CONVERTING-ENZYME; NEMATODE CAENORHABDITIS-ELEGANS; FACTOR-MEDIATED CYTOTOXICITY; BACULOVIRUS P35 PROTEIN; REQUIRE GRANZYME-B; BCL-2 HOMOLOG BAK; BONE-MARROW CELLS; T-CELLS
Publisher's Version: https://doi.org/10.1016/S0163-7258(96)00098-8
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1996-01-01 12:00:00