N-terminal Slit2 promotes survival and neurite extension in cultured peripheral neurons
- Author(s)
- Piper, M; Nurcombe, V; Reid, K; Bartlett, P; Little, M;
- Details
- Publication Year 2002-12-03,Volume 13,Issue #17,Page 2375-2378
- Journal Title
- NEUROREPORT
- Publication Type
- Journal Article
- Abstract
- To investigate the effect of the N-terminal Slit2 protein on neuronal survival and development, recombinant human N-terminal Slit2 (N-Slit2) was assayed against isolated embryonic chick dorsal root ganglion sensory, ciliary ganglion and paravertebral sympathetic neurons. N-Slit2 promoted significant levels of neuronal survival and neurite extension in all of these populations. The protein was also assayed against postnatal mouse dorsal root ganglion neurons and found to promote neuronal survival in a similar manner. These findings suggest the Slit proteins may play an important role during development of the nervous system, mediating cellular survival in addition to the well documented role these proteins play in axonal and neuronal chemorepulsion.
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- AXON GUIDANCE; DROSOPHILA CNS; PROTEIN; MIGRATION; REPELLENT; MIDLINE; EXPRESSION; REPULSION; PRECURSOR
- Publisher's Version
- https://doi.org/10.1097/01.wnr.0000049602.07559.20
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-12-03 12:00:00