B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent Rel/NF-kappa B regulated induction of c-myc transcription
- Author(s)
- Grumont, RJ; Strasser, A; Gerondakis, S;
- Details
- Publication Year 2002-12,Volume 10,Issue #6,Page 1283-1294
- Journal Title
- MOLECULAR CELL
- Publication Type
- Journal Article
- Abstract
- Rel/NF-kappaB transcription factors regulate the division and survival of B lymphocytes. Here we show that B cells lacking NF-kappaB1 and c-Rel fail to increase in size upon mitogenic stimulation due to a reduction in induced c-myc expression. Mitogen-induced B cell growth, although not markedly impaired by FRAP/mTOR or MEK inhibitors, required phosphatidylinositol 3-kinase (PI3K) activity. Inhibition of PI3K-dependent growth coincided with a block in the nuclear import of NF-kappaB1/c-Rel dimers and a failure to upregulate c-myc. In addition, PI3K was shown to be necessary for a transcription-independent increase in c-Myc protein levels that accompanies mitogenic activation. Collectively, these findings establish a role for Rel/NF-kappaB signaling in the mitogen-induced growth of mammalian cells, which in B lymphocytes requires a PI3K/c-myc-dependent pathway.
- Publisher
- CELL PRESS
- Keywords
- TRANSGENIC MICE; SIZE; ONCOGENE; EXPRESSION; APOPTOSIS; RESPONSES; PATHWAY; ANTIGEN; SUBUNIT; DEFECTS
- Publisher's Version
- https://doi.org/10.1016/S1097-2765(02)00779-7
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-12-01 12:00:00