A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production
Details
Publication Year 2002-11, Volume 3, Issue #7, Page 414-418
Journal Title
GENES AND IMMUNITY
Publication Type
Journal Article
Abstract
Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in Tanzanian children having cerebral malaria but not in Kenyan children with severe malaria. Furthermore, homozygotes for the IL12B promotor polymorphism had decreased production of nitric oxide, which is in pad regulated by IL-12 activity. These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population.
Publisher
NATURE PUBLISHING GROUP
Keywords
BLOOD-STAGE MALARIA; PROTECTION; RESPONSES; CHILDREN; SEVERITY; THERAPY
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2002-11-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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