Extracellular signals and pancreatic beta-cell development: A brief review
- Author(s)
- Jiang, FX; Harrison, LC;
- Details
- Publication Year 2002-12-01,Volume 8,Issue #12,Page 763-770
- Journal Title
- MOLECULAR MEDICINE
- Publication Type
- Journal Article
- Abstract
- Cell lineage development is a finely tuned process of proliferation and differentiation, survival and apoptosis, that is regulated by numerous extracellular signals. Here we review some of the extracellular signals-including insoluble cell-cell and extracellular matrix-cell interactions, as well as soluble factors-that appear critical for pancreatic beta-cell development. Knowledge of how these signals control the development of pancreatic endocrine stem/precursor cells into fully functional insulin-secreting beta cells is a platform for the restoration of beta-cell function and the cure therapy of type 1 diabetes.
- Publisher
- JOHNS HOPKINS UNIV PRESS
- Keywords
- BONE MORPHOGENETIC PROTEINS; DYSTROPHIN-GLYCOPROTEIN COMPLEX; ADULT-MOUSE TISSUES; GROWTH-FACTOR; TGF-BETA; IN-VITRO; ALPHA-DYSTROGLYCAN; BASEMENT-MEMBRANES; MOLECULAR-CLONING; GENE-EXPRESSION
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-12-01 12:00:00