Evidence from twins for acquired cellular immune hyperactivity in type 1 diabetes
- Author(s)
- Petrovsky, N; Kyvik, KO; Bonnevie-Nielsen, V; Beck-Nielsen, H; Green, A; Harrison, LC;
- Details
- Publication Year 2002-08,Volume 106,Issue #4,Page 584-589
- Journal Title
- IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Type 1 diabetes has been associated with an increased frequency of activated T cells and T-cell hyperactivity to non-specific and disease-specific stimuli including the islet autoantigen glutamic acid decarboxylase 65 (GAD). To address whether T-cell hyperactivity is genetic or acquired we measured whole blood cytokines in vitro in response to GAD or tetanus in 18 identical twin pairs, nine discordant for type 1 diabetes. In addition, the activity of 2', 5' oligoadenylate synthetase (OAS) in blood mononuclear cells was measured as a marker of viral infection. Interleukin-2 (IL-2) basally and IL-2 and interferon-gamma (IFN-gamma) in response to GAD, were detected more frequently and at higher levels in diabetic compared to non-diabetic twins. IL-10 was not different between groups. OAS activity was increased in diabetic compared to non-diabetic twins and showed a correlation with basal IL-2 and GAD-stimulated IFN-gamma and IL-10. These findings suggest that T-cell hyperactivity in type 1 diabetes is an acquired trait and could reflect persisting virus expression.
- Publisher
- BLACKWELL PUBLISHING LTD
- Keywords
- IDENTICAL-TWINS; COXSACKIE-VIRUS; MELLITUS; DISEASE; ONSET; IDDM; DECARBOXYLASE; LYMPHOCYTES; CONCORDANCE; PREDICTION
- Publisher's Version
- https://doi.org/10.1046/j.1365-2567.2002.01449.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-08-01 12:00:00