Minimal introns are not "junky"
- Author(s)
- Yu, J; Yang, ZY; Kibukawa, M; Paddock, M; Passey, DA; Wong, GKS;
- Details
- Publication Year 2002-08,Volume 12,Issue #8,Page 1185-1189
- Journal Title
- GENOME RESEARCH
- Publication Type
- Journal Article
- Abstract
- Intron-size distributions for most multicellular (and some unicellular) eukaryotes have a sharp peak at their. minimal intron" size. Across the human population, these minimal introns exhibit an abundance of insertion-deletion polymorphisms, the effect of which is to maintain their optimal size. We argue that minimal introns affect function by enhancing the rate at which mRNA is exported from the cell nucleus.
- Publisher
- COLD SPRING HARBOR LAB PRESS
- Keywords
- SINGLE-NUCLEOTIDE POLYMORPHISMS; MESSENGER-RNA; GENOME SEQUENCE; EXPORT; GENES; RECOGNITION; EXPRESSION; MECHANISM; METAZOANS; EVOLUTION
- Publisher's Version
- https://doi.org/10.1101/gr.224602
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-08-01 12:00:00