CD36 is differentially expressed by CD8(+) splenic dendritic cells but is not required for cross-presentation in vivo
- Author(s)
- Belz, GT; Vremec, D; Febbraio, M; Corcoran, L; Shortman, K; Carbone, FR; Heath, WR;
- Details
- Publication Year 2002-06-15,Volume 168,Issue #12,Page 6066-6070
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Cross-presentation allows the processing of Ags from donor cells into the MHC class I presentation pathway of dendritic cells (DCs). This is important for the generation of cytotoxic T cell immunity and for induction of self tolerance. Apoptotic cells are reported to be efficient targets for cross-presentation, and in vitro studies using human DCs have implicated CD36 in their capture. In support of a role for CD36 in cross-presentation, we show that this molecule is differentially expressed by CD8(+) splenic DCs, which previously have been identified as responsible for cross-presentation in the mouse. Three different cross-presentation models were examined for their dependence on CD36. These included cross-priming to OVA-coated spleen cells and cross-tolerance to OVA transgenically expressed in the pancreatic islet beta cells under constitutive conditions or during beta cell destruction. In these models, CD36 knockout DCs were equivalent to wild-type DCs in their capacity to cross-present either foreign or self Ags, indicating that CD36 is not essential for cross-presentation of cellular Ags in vivo.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- T-LYMPHOCYTE RESPONSE; APOPTOTIC CELLS; EXOGENOUS ANTIGEN; SELF-ANTIGENS; IN-VIVO; VITRONECTIN RECEPTOR; CUTTING EDGE; INDUCTION; TOLERANCE; IMMUNITY
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Creation Date: 2002-06-15 12:00:00