Bethesda proposals for classification of lymphoid neoplasms in mice
- Author(s)
- Morse, HC; Anver, MR; Fredrickson, TN; Haines, DC; Harris, AW; Harris, NL; Jaffe, ES; Kogan, SC; MacLennan, ICM; Pattengale, PK; Ward, JM;
- Details
- Publication Year 2002-07-01,Volume 100,Issue #1,Page 246-258
- Journal Title
- BLOOD
- Publication Type
- Journal Article
- Abstract
- A consensus system for classification of mouse lymphoid neoplasms according to their histopathologic and genetic features has been an elusive target for investigators involved in understanding the pathogenesis of spontaneous cancers or modeling human hematopoietic diseases in mice. An international panel of scientists with expertise in mouse and human hematopathology joined with the hematopathology subcommittee of the Mouse Models for Human Cancers Consortium to develop criteria for definition and classification of these diseases together with a standardized nomenclature. The fundamental elements contributing to the scheme are clinical features, morphology, immunophenotype, and genetic characteristics. The resulting classification has numerous parallels to the World Health Organization classification of human lymphoid tumors while recognizing differences that may be species specific. The classification should facilitate communications about mouse models of human lymphoid diseases.
- Publisher
- AMER SOC HEMATOLOGY
- Keywords
- B-CELL LYMPHOMAS; MARGINAL ZONE; C57BL/6 MICE; IMMUNODEFICIENCY SYNDROME; NATURAL-KILLER; MURINE AIDS; T-CELLS; LEUKEMIA; MOUSE; MODEL
- Publisher's Version
- https://doi.org/10.1182/blood.V100.1.246
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-07-01 12:00:00