Leukemia inhibitory factor and interleukin-11: cytokines with key roles in implantation
- Author(s)
- Robb, L; Dimitriadis, E; Li, RL; Salamonsen, LA;
- Details
- Publication Year 2002-10,Volume 57,Issue #1-2,Page 129-141
- Journal Title
- JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Members of the interleukin-6 family of cytokines include leukaemia inhibitory factor (LIF), interleukin-6, interleukin-11, cardiotrophin, ciliary neurotropic growth factor, oncostatin M and the recently discovered cardiotropin-like cytokine (NNT-1). These ligands signal via heterodimeric receptors composed of ligand-specific alpha chains and the common signal-transducing subunit gp130. Gene targeting in mice provided the first indication of a role for interleukin 6 family cytokines in implantation with the generation of mice with a null mutation of the gene encoding LIF. LIF null female mice were infertile because of failure of blastocyst implantation. More recently, interleukin-11 signalling has been shown to be required for the uterine decidualization response. This review describes the insights into the role of interleukin-6 family cytokines in female fertility that have come from gene targeting experiments in mice. (C) 2002 Published by Elsevier Science Ireland Ltd.
- Publisher
- ELSEVIER SCI IRELAND LTD
- Keywords
- MOUSE EMBRYO IMPLANTATION; FACTOR GENE-EXPRESSION; HUMAN ENDOMETRIUM; MENSTRUAL-CYCLE; MICE LACKING; MATRIX METALLOPROTEINASES; BLASTOCYST IMPLANTATION; PERIIMPLANTATION PERIOD; TARGETED DISRUPTION; TISSUE INHIBITORS
- Publisher's Version
- https://doi.org/10.1016/S0165-0378(02)00012-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-10-01 12:00:00