Differential regulation of CD36 expression in antigen-presenting cells: Oct-2 dependence in B lymphocytes but not dendritic cells or macrophages
- Author(s)
- Corcoran, L; Vremec, D; Febbraio, M; Baldwin, T; Handman, E;
- Details
- Publication Year 2002-10,Volume 14,Issue #10,Page 1099-1104
- Journal Title
- INTERNATIONAL IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- In mice, three antigen-presenting cell types [B lymphocytes, macrophages and dendritic cells (DC)] express the scavenger receptor CD36. This molecule has been implicated in many important functions, including DC maturation and antigen presentation. In murine B cells, the CD36 gene requires the Oct-2 transcription factor for its expression. We previously found that B cells from Oct-2-null mice display defects in maturation, survival and proliferation. Here we have looked for a possible role for CD36 in B cells, but found that CD36 is dispensable for all responses tested. Although loss of CD36 did not directly affect B cell function, it did modulate slightly the isotype and level of IgG produced in vivo in naive mice, and IgM in Leishmania-infected mice. We also show that in DC and macrophages, CD36 expression is independent of Oct-2. We conclude that CD36 does not play a major role in B cell function, but that CD36 may contribute indirectly to humoral immunity through cells of the innate immune system.
- Publisher
- OXFORD UNIV PRESS
- Keywords
- MURINE CUTANEOUS LEISHMANIASIS; HEAT-STABLE ANTIGEN(HI); MAJOR INFECTION; CD8 EXPRESSION; MOUSE THYMUS; MATURATION; PROGRESSION; METABOLISM; RESISTANCE; SELECTION
- Publisher's Version
- https://doi.org/10.1093/intimm/dxf075
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-10-01 12:00:00