Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites
- Author(s)
- Healer, J; Crawford, S; Ralph, S; McFadden, G; Cowman, AF;
- Details
- Publication Year 2002-10,Volume 70,Issue #10,Page 5751-5758
- Journal Title
- INFECTION AND IMMUNITY
- Publication Type
- Journal Article
- Abstract
- Apical membrane antigen 1 of Plasmodium falciparum (PfAMA1) contains an N-terminal propeptide that is removed prior to the translocation of the mature protein onto the merozoite surface. We localized unprocessed PfAMA1 to the microneme organelles of the intraerythrocytic schizont. The results have suggested that the processed form of PfAMA1 translocates from the microneme compartment independently of another microneme protein, EBA175, which is also involved in the invasion of human erythrocytes.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- APICAL MEMBRANE ANTIGEN-1; ERYTHROCYTE BINDING ANTIGEN; TOXOPLASMA-GONDII; MOLECULAR CHARACTERIZATION; MONOCLONAL-ANTIBODIES; HOST-CELLS; INVASION; KNOWLESI; SURFACE; LOCALIZATION
- Publisher's Version
- https://doi.org/10.1128/IAI.70.10.5751-5758.2002
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-10-01 12:00:00