Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E mu-v-abl transgenic mice

Author(s): Symons, RCA; Daly, MJ; Fridlyand, J; Speed, TP; Cook, WD; Gerondakis, S; Harris, AW; Foote, SJ;
Details: Publication Year 2002-08-20,Volume 99,Issue #17,Page 11299-11304
Journal Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication Type: Journal Article
Abstract: There is a great difference insusceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F-2 hybrid mice, and have mapped at least six loci on chromosomes 2, 4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males were found to be more prone to plasmacytomagenesis. Different loci influence tumor susceptibility in male and female mice. Survival in females may be largely controlled by a pair of interacting loci on chromosomes 2 and 17.
Publisher: NATL ACAD SCIENCES
Keywords: MOUSE; RESISTANCE; TUMORIGENESIS; INDUCTION; IDENTIFICATION; CHROMOSOME-4; P16(INK4A); PRISTANE; PLA2G2A; REGION
Publisher's Version: https://doi.org/10.1073/pnas.162566999
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2002-08-20 12:00:00