The BCL2 family: Regulators of the cellular life-or-death switch
- Details
- Publication Year 2002-09,Volume 2,Issue #9,Page 647-656
- Journal Title
- NATURE REVIEWS CANCER
- Publication Type
- Journal Article
- Abstract
- Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- CYTOCHROME-C RELEASE; CHANNEL-FORMING ACTIVITY; IN-VIVO; CAENORHABDITIS-ELEGANS; ENDOPLASMIC-RETICULUM; INDUCE APOPTOSIS; TRANSGENIC MICE; DEFICIENT MICE; BH3 DOMAIN; X-L
- Publisher's Version
- https://doi.org/10.1038/nrc883
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-09-01 12:00:00