Growth of rotaviruses in primary pancreatic cells
- Author(s)
- Coulson, BS; Witterick, PD; Tan, Y; Hewish, MJ; Mountford, JN; Harrison, LC; Honeyman, MC;
- Details
- Publication Year 2002-09,Volume 76,Issue #18,Page 9537-9544
- Journal Title
- JOURNAL OF VIROLOGY
- Publication Type
- Journal Article
- Abstract
- Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- NEUTRALIZING MONOCLONAL-ANTIBODIES; INDUCED DIABETES-MELLITUS; T-CELL; BETA-CELLS; REOVIRUS INFECTION; BILIARY ATRESIA; NOD MICE; VIRUS; ATTACHMENT; CHILDREN
- Publisher's Version
- https://doi.org/10.1128/JVI.76.18.9537-9544.2002
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-09-01 12:00:00