Tomacula in MAG-deficient mice
- Author(s)
- Cai, Z; Sutton-Smith, P; Swift, J; Cash, K; Finnie, J; Turnley, A; Thompson, PD; Blumbergs, PC;
- Details
- Publication Year 2002-09,Volume 7,Issue #3,Page 181-189
- Journal Title
- JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
- Publication Type
- Journal Article
- Abstract
- The pathogenesis of tomacula in mice with a null mutation of the myelin-associated glycoprotein (MAG) gene is not well understood. This study, using a novel teased nerve fiber technique, demonstrates that tomacula in MAG-deficient mice are formed by redundant myelin infoldings and outfoldings in the paranodal regions as early as 4 weeks after birth and increase in size and frequency with age. Although tomacula show degenerative changes with increasing age, there was no significant evidence of demyelination/remyelination. Longitudinal sections of normal teased nerve fibers show early redundant myelin foldings in externally normal paranodal regions. These data and the absence of internodal tomacula support a role for MAG in the maintenance of myelin at the paranodal regions.
- Publisher
- WOODLAND PUBLICATIONS, INC
- Keywords
- MYELIN-ASSOCIATED GLYCOPROTEIN; IGM MONOCLONAL GAMMOPATHY; FOCALLY FOLDED MYELIN; LINKED OLIGOSACCHARIDE STRUCTURES; SENSORY NEUROPATHY; PERIPHERAL MYELIN; HEREDITARY NEUROPATHY; PRESSURE PALSIES; PROTEIN ZERO; PARAPROTEINEMIC NEUROPATHY
- Publisher's Version
- https://doi.org/10.1046/j.1529-8027.2002.02023.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-09-01 12:00:00