Activated T cell death in vivo mediated by proapoptotic Bcl-2 family member Bim
- Author(s)
- Hildeman, DA; Zhu, YN; Mitchell, TC; Bouillet, P; Strasser, A; Kappler, J; Marrack, P;
- Details
- Publication Year 2002-06,Volume 16,Issue #6,Page 759-767
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- At the end of the T cell response, the majority of the activated T cells die. We activated Vbeta8(+) T cells with staphylococcal enterotoxin B (SEB) in vivo and monitored the expansion and deletion of Vbeta8(+) T cells. We found that, in response to SEB, activated T cells died in vivo in the absence of Fas or TNF-R signaling but not when they overexpressed human Bcl-2. We also found that Vbeta8(+) T cells from Bim-deficient mice are resistant to SEB-induced deletion. While Bim levels did not change, endogenous Bcl-2 levels within Vbeta8(+) T cells decrease following SEB injection., Thus, the death of superantigen-stimulated T cells in vivo is mediated by Bim and may be modulated by a decrease in Bcl-2.
- Publisher
- CELL PRESS
- Keywords
- IN-VIVO; FAS-LIGAND; BACTERIAL SUPERANTIGEN; APOPTOTIC BCL-2; TRANSGENIC MICE; VIRUS-INFECTION; DOWN-REGULATION; HUMAN TISSUES; SURVIVAL; EXPRESSION
- Publisher's Version
- https://doi.org/10.1016/S1074-7613(02)00322-9
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-06-01 12:00:00