Cutting edge: Conventional CD8 alpha(+) dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1
- Author(s)
- Smith, CM; Belz, GT; Wilson, NS; Villadangos, JA; Shortman, K; Carbone, FR; Heath, WR;
- Details
- Publication Year 2003-05-01,Volume 170,Issue #9,Page 4437-4440
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- CTL play a major role in immunity to HSV type 1, but little is known about the priming process. In this study, we have examined the class I-restricted presentation of an immunodominant determinant from HSV-1 glycoprotein B after footpad infection. We have found that the only cell types capable of presenting this determinant in draining popliteal lymph nodes within the first 3 days after infection are the CD11c(+) CD8alpha(+) CD45RA(-) dendritic cells. Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8alpha(+) dendritic cells are the key subset involved in CTL immunity to this virus.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- CD8(+) T-CELLS; IN-VIVO; ANTIGEN PRESENTATION; IMMUNE-RESPONSES; C57BL/6 MICE; LYMPH-NODES; MOUSE; TYPE-1; MATURATION; PATHOGENS
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2003-05-01 12:00:00