Flt3 ligand-treated neonatal mice have increased innate immunity against intracellular pathogens and efficiently control virus infections
Details
Publication Year 2003-03-03, Volume 197, Issue #5, Page 575-584
Journal Title
JOURNAL OF EXPERIMENTAL MEDICINE
Publication Type
Journal Article
Abstract
Flt-3 ligand (FL), a hematopoetic growth factor, increases the number of dendnitic cells (DCs), B cells, and natural killer cells in adult mice but the effect in neonates was unknown. We show that FL, treatment of newborn mice induced a > 100-fold increase in the innate resistance against infection with herpes simplex virus type 1 and Listeria monocytogenes. This resistance required interferon (IFN)-alpha/beta for viral and interleukin (IL)-12 for bacterial infections. Longterm survival after viral but not bacterial infection was increased similar to100-fold by FL, treatment. After treatment, CD11c(+)/major histocompatibility complex type II+ and CD11c(+)/B220(+) DC lineage cells were the only cell populations increased in the spleen, liver, peritoneum, and skin. DC induction was independent of IFNs, IL-2, -4, -7, -9, -15, and mature T and B cells. The data suggest that FL increases the number of DCs in neonates and possibly in other immune-compromised individuals, which in turn improves IFN-alpha/beta- and IL-12-associated immune responses.
Publisher
ROCKEFELLER UNIV PRESS
Keywords
MATURE DENDRITIC CELLS; HERPES-SIMPLEX VIRUS; LISTERIA-MONOCYTOGENES; NATURAL-KILLER; T-CELLS; PROTECTIVE IMMUNITY; IN-VIVO; ALPHA; DIFFERENTIATION; INTERLEUKIN-12
Rights Notice
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Creation Date: 2003-03-03 12:00:00
Last Modified: 0001-01-01 12:00:00
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