The structural biology of type I viral membrane fusion
- Author(s)
- Colman, PM; Lawrence, MC;
- Details
- Publication Year 2003-04,Volume 4,Issue #4,Page 309-319
- Journal Title
- NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- The fusion of viral membranes with target-cell membranes is an essential step in the entry of enveloped viruses into cells, and recent X-ray structures of paramyxoviral envelope proteins have provided new insights into protein-mediated plasma-membrane fusion. Here, we review our understanding of the structural transitions that are involved in this fusion pathway, compare it to our understanding of influenza virus membrane fusion, and discuss the implications for retroviral membrane fusion.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- HUMAN-IMMUNODEFICIENCY-VIRUS; NEWCASTLE-DISEASE VIRUS; HUMAN PARAINFLUENZA VIRUS; RESPIRATORY SYNCYTIAL VIRUS; SINGLE AMINO-ACID; HEMAGGLUTININ-NEURAMINIDASE PROTEIN; GP120 ENVELOPE GLYCOPROTEIN; INFLUENZA-VIRUS; COILED-COIL; HIV-1 GP41
- Publisher's Version
- https://doi.org/10.1038/nrm1076
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2003-04-01 12:00:00