Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation
- Chong, MMW; Cornish, AL; Darwiche, R; Stanley, EG; Purton, JF; Godfrey, DI; Hilton, DJ; Starr, R; Alexander, WS; Kay, TWH;
Publication Year 2003-04, Volume 18, Issue #4, Page 475-487
- Journal Title
- Publication Type
- Journal Article
- To determine the tissue-specific functions of SOCS-1, mice were generated in which the SOCS-1 gene could be deleted in individual tissues. A reporter gene of SOCS-1 promoter activity was also inserted. Using the reporter, high SOCS-1 expression was found at the CD4(+)CD8(+) stage in thymocyte development. To investigate the function of this expression, the SOCS-1 gene was specifically deleted throughout the thymocyte/T/ NKT cell compartment. Unlike SOCS-1(-/-) mice, these mice did not develop lethal multiorgan inflammation but developed multiple lymphoid abnormalities, including enhanced differentiation of thymocytes toward CD8(+) T cells and very high percentages of peripheral CD8+ T cells with a memory phenotype (CD44(hi)CD25(lo)CD69(lo)). These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines.
- CELL PRESS
- PANCREATIC BETA-CELLS; TUMOR-NECROSIS-FACTOR; IN-VIVO; TRANSGENIC MICE; NATURAL-KILLER; NEGATIVE REGULATION; IFN-GAMMA; MEMORY; LYMPHOCYTES; THYMOCYTES
- Publisher's Version
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Creation Date: 2003-04-01 12:00:00Last Modified: 0001-01-01 12:00:00