Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation
- Author(s)
- Chong, MMW; Cornish, AL; Darwiche, R; Stanley, EG; Purton, JF; Godfrey, DI; Hilton, DJ; Starr, R; Alexander, WS; Kay, TWH;
- Details
- Publication Year 2003-04,Volume 18,Issue #4,Page 475-487
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- To determine the tissue-specific functions of SOCS-1, mice were generated in which the SOCS-1 gene could be deleted in individual tissues. A reporter gene of SOCS-1 promoter activity was also inserted. Using the reporter, high SOCS-1 expression was found at the CD4(+)CD8(+) stage in thymocyte development. To investigate the function of this expression, the SOCS-1 gene was specifically deleted throughout the thymocyte/T/ NKT cell compartment. Unlike SOCS-1(-/-) mice, these mice did not develop lethal multiorgan inflammation but developed multiple lymphoid abnormalities, including enhanced differentiation of thymocytes toward CD8(+) T cells and very high percentages of peripheral CD8+ T cells with a memory phenotype (CD44(hi)CD25(lo)CD69(lo)). These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines.
- Publisher
- CELL PRESS
- Keywords
- PANCREATIC BETA-CELLS; TUMOR-NECROSIS-FACTOR; IN-VIVO; TRANSGENIC MICE; NATURAL-KILLER; NEGATIVE REGULATION; IFN-GAMMA; MEMORY; LYMPHOCYTES; THYMOCYTES
- Publisher's Version
- https://doi.org/10.1016/S1074-7613(03)00078-5
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2003-04-01 12:00:00