The lethal effects of transplantation of Socs1(-/-) bone marrow cells into irradiated adult syngeneic recipients
- Author(s)
- Metcalf, D; Mifsud, S; Di Rago, L; Alexander, WS;
- Details
- Publication Year 2003-07-08,Volume 100,Issue #14,Page 8436-8441
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- Injection of neonatal bone marrow cells from mice lacking the gene encoding suppressor of cytokine signaling 1 (SOCS1) into irradiated syngeneic 129/Sv or C57BL/6 mice led to a decreased survival, more rapidly occurring in 129/Sv than in C57BL/6 mice. Moribund mice did not exhibit the acute or chronic diseases developed by Socs1(-/-) mice but developed a pathology characteristic of graft-versus-host disease with typical chronic inflammatory lesions in the liver, skin, lungs, and gut. The results indicate that cells derived from the Socs1(-/-) bone marrow are autoaggressive but did not identify the cell types involved. Failure of the engrafted Socs1(-/-) marrow cells to reproduce the tissue damage typical of Socs1(-/-) disease indicates that loss of SOCS1 from target tissues may also be required for the development of the Socs1(-/-) diseases, such as fatty degeneration of the liver, polymyositis, or corneal inflammation.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- CYTOKINE SIGNALING-1; IFN-GAMMA; RADIATION CHIMERAS; GENETIC-VARIATION; INTERFERON-GAMMA; 129 SUBSTRAINS; MICE; SUPPRESSOR; DIFFERENTIATION; DEGENERATION
- Publisher's Version
- https://doi.org/10.1073/pnas.1032925100
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2003-07-08 12:00:00