The lethal effects of transplantation of Socs1(-/-) bone marrow cells into irradiated adult syngeneic recipients
Details
Publication Year 2003-07-08, Volume 100, Issue #14, Page 8436-8441
Journal Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication Type
Journal Article
Abstract
Injection of neonatal bone marrow cells from mice lacking the gene encoding suppressor of cytokine signaling 1 (SOCS1) into irradiated syngeneic 129/Sv or C57BL/6 mice led to a decreased survival, more rapidly occurring in 129/Sv than in C57BL/6 mice. Moribund mice did not exhibit the acute or chronic diseases developed by Socs1(-/-) mice but developed a pathology characteristic of graft-versus-host disease with typical chronic inflammatory lesions in the liver, skin, lungs, and gut. The results indicate that cells derived from the Socs1(-/-) bone marrow are autoaggressive but did not identify the cell types involved. Failure of the engrafted Socs1(-/-) marrow cells to reproduce the tissue damage typical of Socs1(-/-) disease indicates that loss of SOCS1 from target tissues may also be required for the development of the Socs1(-/-) diseases, such as fatty degeneration of the liver, polymyositis, or corneal inflammation.
Publisher
NATL ACAD SCIENCES
Keywords
CYTOKINE SIGNALING-1; IFN-GAMMA; RADIATION CHIMERAS; GENETIC-VARIATION; INTERFERON-GAMMA; 129 SUBSTRAINS; MICE; SUPPRESSOR; DIFFERENTIATION; DEGENERATION
Rights Notice
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Creation Date: 2003-07-08 12:00:00
Last Modified: 0001-01-01 12:00:00
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