CD8 alpha(+) mouse spleen dendritic cells do not originate from the CD8 alpha(-) dendritic cell subset
- Author(s)
- Naik, S; Vremec, D; Wu, L; O'Keeffe, M; Shortman, K;
- Details
- Publication Year 2003-07-15,Volume 102,Issue #2,Page 601-604
- Journal Title
- BLOOD
- Publication Type
- Journal Article
- Abstract
- Although previous studies had indicated that the CD8alpha(-) and CD8alpha(+) subtypes of murine dendritic cells (DCs) differ in immediate origin, a recent study found that intravenous transfer of CD8alpha(-) DCs led to CD8alpha(+) DCs in the spleen several days later, suggesting a direct precursor-product relationship. We have repeated these experiments with a balance sheet approach. We find that though a few CD8alpha(+) DCs can be generated in such experiments, this is a rare event and could be the result of a contaminant precursor. Most of the immediate precursors of CD8alpha(+) DCs are cells that lack the phenotype of a recognizable DC. CD8alpha(-) DCs and CD8alpha(+) DCs are not precursor-product related, though these sublineages may be connected further upstream. (C) 2003 by The American Society of Hematology.
- Publisher
- AMER SOC HEMATOLOGY
- Keywords
- IN-VIVO; POPULATIONS; MATURATION; PHENOTYPE; MICE
- Publisher's Version
- https://doi.org/10.1182/blood-2002-10-3186
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2003-07-15 12:00:00