Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex

Author(s): Hansen, DS; Siomos, MA; Buckingham, L; Scalzo, AA; Schofield, L;
Details: Publication Year 2003-03,Volume 18,Issue #3,Page 391-402
Journal Title: IMMUNITY
Publication Type: Journal Article
Abstract: NKT cells are specialized cells coexpressing NK and T cell receptors. Upon activation they rapidly produce high levels of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) and are therefore postulated to influence T(H)1/T(H)2 immune responses. The precise role of the CD1/NKT cell pathway in immune response to infection remains unclear. We show here that CD1d-restricted NKT cells from distinct genetic backgrounds differentially influence TH1/TH2 polarization, proinflammatory cytokine levels, pathogenesis, and fatality in the P. berghei ANKA/rodent model of cerebral malaria. The functional properties of CD1d-restricted NKT cells vary according to expression of loci of the natural killer complex (NKC) located on mouse chromosome 6, which is shown here to be a significant genetic determinant of murine malarial fatalities.
Publisher: CELL PRESS
Keywords: TUMOR-NECROSIS-FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; T-CELLS; INTERFERON-GAMMA; PLASMODIUM-FALCIPARUM; MONOCLONAL-ANTIBODY; VIRUS-INFECTION; CUTTING EDGE; CRUCIAL ROLE; MOUSE
Publisher's Version: https://doi.org/10.1016/S1074-7613(03)00052-9
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2003-03-01 12:00:00