The role of Rel/NF-kappa B transcription factors in B lymphocyte survival
- Author(s)
- Gerondakis, S; Strasser, A;
- Details
- Publication Year 2003-06,Volume 15,Issue #3,Page 159-166
- Journal Title
- SEMINARS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Among the transcriptional mediators of the various signal transduction pathways that have been shown to regulate lymphocyte apoptosis, Rel/NF-kappaB transcription factors have emerged as key regulators of B cell survival during their differentiation and in their activation by antigens or mitogens. The aim of this review is to bring together recent findings on Rel/NF-kappaB regulation of B cell survival and to present an intearated model of how these transcription factors control apoptosis in a signal and differentiation-stage specific manner. In addition to providing a contemporary view of Rel/NF-kappaB regulated B cell survival, the model described here is aimed to serve as a paradigm for how Rel/NF-kappaB family members control survival in different cell types during differentiation and in response to the plethora of signals that impinge on this master transcriptional regulatory pathway. (C) 2003 Elsevier Science Ltd. All rights reserved.
- Publisher
- ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
- Keywords
- CELL DEVELOPMENT; MICE LACKING; BCL-X; C-REL; APOPTOSIS; ACTIVATION; RECEPTOR; EXPRESSION; DEFICIENT; FAMILY
- Publisher's Version
- https://doi.org/10.1016/S1044-5323(03)00036-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2003-06-01 12:00:00