Proinsulin - a pathogenic autoantigen in type 1 diabetes
- Author(s)
- Narendran, P; Mannering, SI; Harrison, LC;
- Details
- Publication Year 2003-06,Volume 2,Issue #4,Page 204-210
- Journal Title
- AUTOIMMUNITY REVIEWS
- Publication Type
- Journal Article
- Abstract
- Type 1 diabetes (T1D) is an autoimmune disease characterised by immunity to pancreatic beta-cell autoantigens, associated with beta-cell destruction leading to insulin deficiency and hyperglycaemia. The rigorous definition of, an autoimmune disease I requires evidence that an autoantigen, elicits pathological immune responses. Using criteria for the pathogenicity of an autoantigen, we examine. the evidence for proinsulin as an autoantigen in T1D. We conclude, that proinsulin satisfies these criteria. As a corollary proinsulin is a potential immunotherapeutic tool for, the prevention of T1D. (C) 2003 Elsevier B.V. All rights reserved.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- CELLULAR IMMUNE-RESPONSES; INSULIN AUTOANTIBODIES; TRANSGENIC MICE; NOD MICE; T-CELLS; EXPRESSION; LOCUS; RISK; INDIVIDUALS; EPITOPES
- Publisher's Version
- https://doi.org/10.1016/S1568-9972(03)00009-0
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2003-06-01 12:00:00